2,2'-Azobis(2-methylpropionamidine) dihydrochloride
2,2'-azobis[2-methylpropionamidine] dihydrochloride
CAS: 2997-92-4
Molecular Formula: C8H20Cl2N6
2,2'-Azobis(2-methylpropionamidine) dihydrochloride - Names and Identifiers
| Name | 2,2'-azobis[2-methylpropionamidine] dihydrochloride |
| Synonyms | V50 AIBA AAPH 2,2'-AZOBIS-(2-AMIDINOPROPANE), 2HCL Azo two isobutyl Acetamiprid hydrochloride 2,2'-AZOBIS-(2-AMIDOPROPANE) HYDROCHLORIDE 2,2'-AZOBIS(ISOBUTYRAMIDINE) DIHYDROCHLORIDE 2,2'-AZOBIS(2-AMIDINOPROPANE) DIHYDROCHLORIDE 2,2-azobis(2-methylpropionamidine)dihydrochlorid 2,2'-Azobis(2-methylpropionamide)dihydrochloride 2,2'-azobis(2-methyl-propionamidindihydrochloride 2,2'-azobis[2-methyl-propanimidamiddihydrochloride 2,2'-azobis(2-methyl-propanimidamiddihydrochloride 2,2'-AZOBIS(2-METHYLPROPIONAMIDINE) DIHYDROCHLORIDE 2,2'-Azobis(2-Methylpropionamidine) Dihydrochloride 2,2'-azobis[2-methylpropionamidine] dihydrochloride 2-(2-amino-2-imino-1,1-dimethyl-ethyl)azo-2-methyl-propanamidine dihydrochloride |
| CAS | 2997-92-4 |
| EINECS | 221-070-0 |
| InChI | InChI=1/C8H18N6.2ClH/c1-7(2,5(9)10)13-14-8(3,4)6(11)12;;/h1-4H3,(H3,9,10)(H3,11,12);2*1H |
| InChIKey | LXEKPEMOWBOYRF-QDBORUFSSA-N |
2,2'-Azobis(2-methylpropionamidine) dihydrochloride - Physico-chemical Properties
| Molecular Formula | C8H20Cl2N6 |
| Molar Mass | 271.19 |
| Density | 0.42 |
| Melting Point | 175-177°C(lit.) |
| Boling Point | 336.4°C at 760 mmHg |
| Flash Point | 157.3°C |
| Water Solubility | 176.2g/L at 20℃ |
| Solubility | acetone, dioxane, methanol, ethanol, DMSO and water: soluble |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | White Crystal |
| Color | White to off-white |
| Storage Condition | 0-6°C |
| Stability | Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids. |
| Sensitive | Sensitive to light |
| MDL | MFCD00142725 |
| Use | Synthetic intermediates for chemicals such as pharmaceuticals and dyes. Initiator, acrylic acid, vinyl, allyl monomer polymerization initiator. |
2,2'-Azobis(2-methylpropionamidine) dihydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact R5 - Heating may cause an explosion |
| Safety Description | S24 - Avoid contact with skin. S37 - Wear suitable gloves. |
| UN IDs | UN 3226 4.1 |
| WGK Germany | 1 |
| RTECS | UE4575500 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29270000 |
| Hazard Class | 5.1 |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 410mg/kg |
2,2'-Azobis(2-methylpropionamidine) dihydrochloride - Reference
| Reference Show more | 1. Yan Heng, Liu Jingjing, Shen Zhengyu, Zhang Rui, Hu Yingying, Xie Weihong. Preparation and evaluation of adsorption properties of Molecularly Imprinted Polymer with core-shell Red [J]. Journal of Analytical Science, 2017,33(06):785-789. 2. Jiang Guozhe, Quan Zhenyu, Jin Runhao, HONG Heedo, Han Chunji. Fermentation conditions and antioxidant activity of Lactobacillus pentosus extracted from Rhodiola rosea and codonopsis lanceolata [J]. Food Science, 2018,39(02):124-130. 3. Liu Shanshan, AO Jing, Xie Ningning, etc. Study on gastrointestinal digestive stability of casein antioxidant peptides [J]. Chinese Journal of Food Science, 2014, 14(002):47-54. 4. Liu Shanshan, Li Bo. Study on gastrointestinal tolerance of highly active antioxidant peptides in vitro [J]. Food Science and Technology, 2014, 039(001):1-9. 5. Huoyanyu, Wang Bo, Guo Shanshan, etc. Antioxidant activity and bioavailability of fish protein peptides during simulated gastrointestinal digestion and absorption [J]. Science and Technology of Food Industry, 2016, 37(006):174-178. 6. Chen Xi-Miao, Li Mei-ying, Xu Qiu-Li, et al. Changes of polyphenols and antioxidant activity of Hawthorn during simulated gastrointestinal digestion in vitro [J]. Food Science, 2019, 040(005):31-37. 7. Zang Jia, Zang Junbo, Shi Junjun, etc. Stability of fennel essential oil in accelerated oxidation environment and its antioxidant screening [J]. Chinese Journal of Experimental prescriptions, 2019, 3 (18). 8. Wang Yu, Zou Junbo, Shi Yaojun, Zhang Xiaofei, Yan Jia, Liang Yulin, Guo Dongyan. Study on accelerated oxidation stability of turmeric volatile oil and screening of antioxidants [J]. Chinese herbal medicines, 2019,42(11):2627-2630. 9. Zhang Yu. Preparation and application of "active" polymer by RAFT controlled polymerization [D]. Hubei University of Technology, 2020. 10. Shen, Jie, et al. "Investigation of cationic soapless P (St-co-DMAEMA) latex and its electrostatic adsorption of laponite." Chinese Journal of Polymer Science 34.10 (2016): 1240-1250. 11. [IF=6.475] Ying Wu et al."Comparison and screening of bioactive phenolic compounds in different blueberry cultivars: Evaluation of anti-oxidation and α-glucosidase inhibition effect."Food Res Int. 2017 Oct;100:312 12. [IF=3.603] Shen Jie et al."Investigation of cationic soapless P(St-co-DMAEMA) latex and its electrostatic adsorption of laponite."Chinese J Polym Sci. 2016 Oct;34(10):1240-1250 13. [IF=9.381] Fanke Zeng et al."Structural characterization of polysaccharides with potential antioxidant and immunomodulatory activities from Chinese water chestnut peels."Carbohyd Polym. 2020 Oct;246:116551 14. [IF=7.514] Yongfang Ren et al."Antioxidant activity, stability, in vitro digestion and cytotoxicity of two dietary polyphenols co-loaded by β-lactoglobulin."Food Chem. 2022 Mar;371:131385 15. [IF=6.953] Zhou Dong et al."Purification and comparative study of bioactivities of a natural selenized polysaccharide from Ganoderma Lucidum mycelia."Int J Biol Macromol. 2021 Nov;190:101 16. [IF=5.279] Yun-Feng Zheng et al."Comprehensive Comparison of Two Color Varieties of Perillae Folium Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q/TOF-MS)-Based Metabolic Profile and in Vivo/in Vitro Anti 17. [IF=4.952] Yingjie Bao et al."Comparison of lipid radical scavenging capacity of spice extract in situ in roast beef with DPPH and peroxy radical scavenging capacities in vitro models."Lwt Food Sci Technol. 2020 Aug;130:109626 18. [IF=4.411] Xia Niu et al."Novel IMB16-4 Compound Loaded into Silica Nanoparticles Exhibits Enhanced Oral Bioavailability and Increased Anti-Liver Fibrosis In Vitro."Molecules. 2021 Jan;26(6):1545 19. [IF=3.125] Lingxiao Li et al."Thiol functionalized polymer submicron particles prepared by soap-free emulsion polymerization and their adsorption of lead ions in water."J Appl Polym Sci. 2020 Nov;137(43):49312 20. [IF=4.451] Yongfang Ren et al."Functional improvement of (−)-epicatechin gallate and piceatannol through combined binding to β-lactoglobulin: Enhanced effect of heat treatment and nanoencapsulation."Journal of Functional Foods. 2022 Jul;94:105120 |
2,2'-Azobis(2-methylpropionamidine) dihydrochloride - Reference Information
Open Data Unverified Data
| LogP | 0.3 at 25℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | at present, the conventional preparation process of azodiisobutylamidine hydrochloride is generally carried out in three steps: the first step is to oxidize hydrogenated azonitrile to azonitrile with oxidant such as chlorine or hydrogen peroxide; The second step is to carry out pinner reaction in the presence of methanol and hydrogen chloride to obtain azoiminite hydrochloride; the third step is to disperse azoimine ether hydrochloride with alcohol and then pass ammonia gas to obtain azodiisobutylamidine hydrochloride. The process has many disadvantages, such as long route, difficult control, large amount of wastewater, not conducive to environmental protection, relatively low yield, not suitable for industrial scale production and so on. |
| Uses | Azo diisobutylamidine hydrochloride is a free radical initiator in biochemical reactions, biochemical research, used as an initiator for polymerization reactions. Synthetic medicine, dyes and other chemical intermediates, initiators, acrylic acid, vinyl, allyl monomer polymerization initiators. Free radical initiator in biochemical reaction. Biochemical research Used as an initiator for polymerization reactions An intermediate for the synthesis of chemicals such as medicines and dyes. Initiator, acrylic acid, vinyl, allyl monomer polymerization initiator. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 410 mg/kg |
| stimulation data | skin-rabbit 500 mg mild |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxides and hydrogen chloride smoke |
| storage and transportation characteristics | ventilation and low temperature drying; separate from warehouse food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 19:43:38
2,2'-Azobis(2-methylpropionamidine) dihydrochloride - Introduction
Easily soluble in water, insoluble in organic solvents · Easily soluble in water, insoluble in organic solvents · First-order decomposition can occur to form cationic free radicals. Under ultraviolet light? Solution. Compatible with cationic surfactants. The rate of decomposition depends on the pH.
Last Update：2022-10-16 17:24:23
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